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MUSE® technology
Multiplex Universal Signal Enhancement

Biomarker detection is often restricted by sensitivity (critical for low-abundance biomarkers as HER2-low or smFISH on FFPE), specificity (batch variation of secondary antibodies) and multiplexing possibilities.

MUSE® (Multiplex Universal Signal Enhancement) technology was invented to overcome these difficulties.

MUSE® is an enzyme-free self-assembling DNA nanotechnology which can be used to detect several proteins as well as nucleic acids, from 1-plex  to 7-plex in one cycle.

MUSE® can be applied in a variety of assays: IHC, IF, FISH, IMC, FACS and more.
 

MUSE® benefits at a glance:

  • Ultra sensitivity 

  • Real multiplex imaging​

  • Label flexibility​

  • Same day results

  • Large spectrum of applications​

  • For any biomarker​

  • Simple & Robust​

  • Batch consistency

  • Sustainability

MUSE®- how does it work?

Our patented MUSE® reaction drives the enzyme-free assembly of hyperbranched polymers that attach numerous fluorophores, chromogenic enzymes or alternative contrast agents to probe-ligand complexes. The MUSE® reaction is error-corrected by a key and lock molecular mechanism that ensures precise background control and orthogonality and a very low signal-to-noise ratio.
MUSE® is a robust, quick and simple reaction: two steps, room temperature, no enzymes, no specialized equipment.

MUSE technology

MUSE® customer testimonials

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